High T cell variety associated with improved response and fewer side effects in NSCLC
Patients with advanced non-small cell lung cancer (NSCLC) may benefit from immune checkpoint inhibition, but many end up with immune-related side effects, highlighting a need to identify potential risk factors. Patients with higher T cell receptor (TCR) richness in their peripheral blood have improved outcomes, but the characteristics of TCR and their role in side effects is poorly understood. In the LONESTAR clinical trial, researchers led by Mehmet Altan, M.D., Alexandre Reuben, Ph.D., John Heymach, M.D., Ph.D., and Jianjun Zhang, M.D., Ph.D.,...