High T cell variety associated with improved response and fewer side effects in NSCLC

Patients with advanced non-small cell lung cancer (NSCLC) may benefit from immune checkpoint inhibition, but many end up with immune-related side effects, highlighting a need to identify potential risk factors. Patients with higher T cell receptor (TCR) richness in their peripheral blood have improved outcomes, but the characteristics of TCR and their role in side effects is poorly understood.   In the LONESTAR clinical trial, researchers led by Mehmet Altan, M.D., Alexandre Reuben, Ph.D., John Heymach, M.D., Ph.D., and Jianjun Zhang, M.D., Ph.D.,...

Biomarker levels provide insights into neuroendocrine tumor progression

Patients with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) – rare tumors that develop in the pancreas or gastrointestinal tract – are routinely monitored for disease progression using imaging tests. Circulating chromogranin A (CgA) is an established biomarker for these tumors, but there are mixed results in using serum or plasma CgA to monitor disease progression.   In the prospective, multicenter CASPAR study, Qing Meng, Ph.D., and colleagues examined imaging tests from 153 patients with well-differentiated GEP-NET and validated an...

CTLA-4 blockade generates greater memory response than PD-1 blockade

Immune checkpoint inhibitors targeting CTLA-4 and PD-1, which stimulate the body’s own T cells to eliminate cancer, are an efficient treatment strategy for many cancers. Notably, CTLA-4 blockade seemingly leads to more durable responses compared to PD-1 blockade.   Some studies suggest this could be attributed to differing memory CD8 T cell responses from each strategy, but the mechanisms remain unclear. In a new study, researchers led by Stephen Mok, Ph.D., and James Allison, Ph.D., used tumor...

Mutation drives granulosa cell tumor growth, highlighting potential therapeutic targets

Adult granulosa cell tumors (AGCTs) constitute a rare type of ovarian cancer that typically involves a specific mutation in the FOXL2 gene, which disrupts ovarian function and can lead to incurable relapse. However, it is not well understood how this specific mutation is able to promote cancer cell growth. To provide further mechanistic insights, researchers led by Tyler Hillman, M.D., Ph.D., examined cell lines of relapsed AGCT with this specific mutation.   They found that the mutation causes the FOXL2...

Dynamics of the INO80 chromatin remodeler in restructuring chromatin highlight potential therapeutic target

DNA is wrapped into nucleosomes that form chromatin and are rearranged by protein complexes. The INO80 chromatin remodeler enzyme moves nucleosomes along DNA and modifies its protein composition, which is important for many processes including gene regulation and cell differentiation. To better understand how INO80 modifies the protein composition of nucleosomes, researchers led by Blaine Bartholomew, Ph.D., discovered that Arp5 – a protein subunit of INO80 – dynamically rotates, thereby switching the region of Arp5 contacting the nucleosome.   If...

UTMB pathologists use AI-enabled tool to help diagnose prostate cancer

UTMB pathologists recently began using an AI-based tool from Ibex to create digital overlays of every prostate biopsy that comes through the lab.   Pathologists can examine these biopsy images on a computer screen, along with Ibex-generated colored overlays. This process allows pathologists to make more accurate diagnoses of prostate cancer, according to Dr. Harsh Thaker, vice chair for digital and integrative pathology.   In fact, Thaker said he has already seen the new tool...

Monoclonal antibody therapy improves survival in cancer-associated hyper-inflammatory disorder

Adult patients with newly diagnosed malignancy-associated hemophagocytic lymphohistiocytosis (mHLH) – a rare, aggressive hyperinflammatory condition – who were treated with the first-in-class monoclonal antibody, ELA026, experienced a 100% response rate and an improved survival rate at two months, according to researchers from The University of Texas MD Anderson Cancer Center.   Findings suggest that early intervention with ELA026 may provide meaningful clinical benefits for patients with few options.   “It is common for patients with mHLH...

Rice study reveals vital link for dementia spousal caregivers

A new Rice University study sheds light on the critical role marital relationships play in the mental and physical health of caregivers for spouses living with dementia, revealing that caregiver mental health dramatically improves when carers feel supported, understood and appreciated by their loved ones requiring care. The research was led by Vincent Lai, a graduate student in psychological sciences at Rice. The study involved 161 spousal caregivers and explored the unique challenges they face....

Definitive radiotherapy demonstrates effectiveness in metastatic thyroid cancers

Definitive radiotherapy (dRT), intended for long-term disease control, is an effective option for several solid tumors that are oligometastatic, meaning they have limited metastatic lesions, or oligoprogressive, meaning few metastases are progressing. However, the benefit of dRT for metastatic thyroid cancers is largely unknown. Researchers led by Matthew Ning, M.D., examined the use of targeted dRT using stereotactic body radiotherapy (SBRT) in 119 patients with oligometastatic/oligoprogressive thyroid cancer.   Treatment with dRT showed a 91% local control rate for treated sites at...

Targeting signaling pathway may overcome treatment resistance in pancreatic cancer

Many patients with late-stage pancreatic cancer develop resistance to various treatments including first-line chemotherapy, highlighting a need to identify and understand the mechanisms of resistance. To provide insights, researchers led by Yohei Saito, Ph.D., Yi Xiao, Ph.D., and Dihua Yu, M.D., Ph.D., examined single-cell transcriptomic data from models of pancreatic cancer and clinical pathological information from patients with pancreatic cancer.   They discovered a novel signaling circuit – Yap1 in cancer cells and Cox2 in fibroblasts of tumor microenvironment...

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