A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates for patients with refractory CD30-positive lymphomas.   Results from the Phase I trial demonstrated an overall response rate of 92.9% and a complete response of 66.7% in 42 heavily pretreated patients. These findings suggest this unique cell therapy approach has promise for specific patients with lymphoma, but it may...

New research out of the University of Texas Medical Branch reveals findings that drug candidate NITD-688 utilized a unique way to stop dengue, a potentially life-threatening infection spread by mosquitos.   Dengue, caused by the dengue virus, presents a significant public health challenge with limited effective treatments. Primarily transmitted to humans through the bite of infected mosquitoes, the virus can cause diseases ranging from mild flu-like illness to life-threatening dengue hemorrhagic fever and dengue shock syndrome....

Surgery may not be the best next course of treatment for patients with early-stage breast cancer who had a complete response to neoadjuvant (pre-surgical) chemotherapy and standard radiation treatment.   Five-year results from the Phase II trial revealed that breast cancer still had not returned in patients who had a pathologic complete response (pCR) after chemotherapy and radiation, without surgery. After a median follow-up of 55.4 months, each of the 31 patients with a pCR remained disease...

Houston Methodist recently announced that it has awarded $10 million in community grants to 30 local nonprofit organizations through the Community Benefits Grant Program. In 2025, the agencies receiving grant support will help more than 59,000 individuals in the Greater Houston area gain access to critical health care services.   The Community Benefits Grant Program focuses on increasing health care access to primary care and mental health care services for uninsured and underinsured individuals through financial support...

Texas Children’s Hospital and The University of Texas MD Anderson Cancer Center have announced a transformational collaboration dedicated solely to pediatric cancer care. Approved by the Texas Children’s Board of Trustees and the UT System Board of Regents, this new, first-of-its-kind joint venture will unite the nation’s largest comprehensive pediatric system and a top pediatric cancer program with the nation’s leading comprehensive cancer center. The collaboration has a single mission: to end childhood cancer.   “The scope and scale of our combined...

The University of Texas MD Anderson Cancer Center and Texas Children’s Hospital have announced a transformational collaboration dedicated solely to pediatric cancer care. Approved by the UT System Board of Regents and the Texas Children’s Board of Trustees, this new, first-of-its-kind joint venture will unite the nation’s largest comprehensive pediatric system and a top pediatric cancer program with the nation’s leading comprehensive cancer center. The collaboration has a single mission: to end childhood cancer. “The scope and scale of...

The University of Texas MD Anderson Cancer Center and Myriad Genetics, Inc. announced a five-year strategic alliance to accelerate the clinical evaluation and development of Myriad’s molecular residual disease (MRD) assay.   This strategic alliance brings together the longstanding oncology diagnostic experience of Myriad Genetics and the clinical and translational research expertise of MD Anderson to create a portfolio of studies to evaluate the clinical validity and utility of Myriad’s PreciseMRD.   “We look forward to...

The omentum – a fatty tissue that suspends from the stomach – is a common site of metastasis for abdominal cancers, especially ovarian cancers. The omentum contains abundant clusters of immune cells, but it is unclear why they do not effectively defend against cancer cells. In a new study, researchers led by WonJae Lee, Ph.D., and  Honami Naora, Ph.D., showed that neutrophils release webs of DNA called neutrophil extracellular traps (NETs) that specifically attract innate-like B...

A new biomarker study provides novel insights into how dose-dense chemotherapy can improve survival for some patients with estrogen receptor (ER)-positive breast cancer. In the study, researchers analyzed 12-year follow-up data from the Phase III CALGB 9741 trial, which included 1,973 patients with node-positive, early-stage breast cancer.   The results showed that dose-dense chemotherapy, given every two weeks instead of the standard three-week schedule, improved disease-free survival by 20% and overall survival by 15%. Using a biomarker test developed at...

Many patients with metastatic renal cell carcinoma are treated with immune checkpoint inhibitors as part of their systemic regimens, but only a small subset of patients achieve durable long-term or curative responses. To identify molecular biomarkers for these exceptional responders and better predict which patients benefit most, researchers led by Sachet Shukla, Ph.D., utilized whole-exome and RNA sequencing to analyze pre-treatment tumor samples and matched germline samples from treated patients in two clinical trials.   The researchers identified...