Study identifies novel intermediates involved in genetic crossovers in mammals

September 14, 20231 min
3d illustration of X chromosomes

Genetic crossovers – the exchange of DNA between pairs of chromosomes from each parent – play a crucial role in accurate chromosome segregation during meiotic cell division. However, the mechanisms underlying the formation of these crossovers in mammals are poorly understood. To provide further insight into this process, researchers led by Francesca Cole, Ph.D., used genetic dissection to map the frequency and distribution of crossover points in mouse models.

The researchers discovered two unique intermediate steps that occur prior to recombination. Additionally, they highlighted the DNA mismatch repair protein MLH3 as a pivotal structural component required to form the junctions involved in recombination. These findings help refine the current understanding of recombination in mammals, advancing knowledge of how genes are transferred during meiosis.

MJH footer logo with red letters

Medical Journal – Houston is the leading source of healthcare business news. With extremely relevant content, late-breaking news and monthly exclusives from industry experts, MJH News has created a winning combination of must-read editorial that physicians and hospital executives eagerly anticipate month after month. MJH News is the resource that provides everything they need in one place, and it is a high honor that they rely upon Medical Journal – Houston to keep their practice or hospital on the cutting edge.

Archives