Researchers have characterized the complex microenvironment in angioimmunoblastic T cell lymphoma (AITL), a type of nodal T cell lymphoma, and identified overexpression of the CD40 protein as a potential biomarker associated with improved overall survival (OS). The study was led by Francisco Vega, M.D., Ph.D., professor of Hematopathology, and Tania Sainz, graduate research assistant.
“The discovery of CD40 overexpression as a potential biomarker gives us a new lens to assess patient risk and opens the door to therapeutic strategies that could improve outcomes for this challenging disease, especially since no biomarkers to predict OS are currently available,” Sainz said.