Distinct classes of fibroblasts in tumors play opposing roles, promoting or restraining pancreatic cancer growth
Researchers at The University of Texas MD Anderson Cancer Center have discovered that two distinct classes of cancer-associated fibroblasts (CAFs) accumulate in the pancreatic tumor microenvironment and play opposing roles to promote and restrain pancreatic cancer development. The preclinical findings suggest that appropriately targeting these unique CAF populations may offer strategies to improve the use of other treatments, such as chemotherapy and immunotherapy. “Cancer-associated fibroblasts are known to regulate cancer progression, but targeting these cells in pancreatic cancer has largely...