DNA shape and rigidity regulate key players of gene expression

Researchers have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the physical structure and shape of DNA, not just genetic information, are key components of DNA transcription. It also suggests that the Arp5 subunits may act as sensors that regulate INO80 remodeling depending on the shape of the DNA. The study was co-led by Blaine Bartholomew, Ph.D., professor of Epigenetics and Molecular Carcinogenesis, and colleagues