New research out of the University of Texas Medical Branch potentially points to an effective treatment for Lassa fever, a dangerous, often fatal disease common to much of West Africa but considered a significant threat to global health. UTMB’s scientists document how a new drug from Zalgen Labs successfully cured cynomolgus monkeys infected with Lassa virus. There currently is no approved treatment for the disease, estimated to infect 300,000 to 500,000 people a year across the region and cause at least 5,000 deaths annually.
Women and children are at the highest risk from Lassa fever, characterized by bleeding and coagulation abnormalities, with overall mortality rates exceeding 25 percent and reaching 50 percent during epidemics. Exposure to infected animals is the most common cause of infection in humans. In a recent study that identified the top 50 agents with pandemic potential, Lassa fever was ranked first among known viruses regarded as a threat to zoonotic spillover.
Though less common, human-to-human transmission is caused through exposure to blood or secretions and sexual contact.
Those in the early stages of the disease often show mild or no symptoms and therefore do not seek help until their condition is advanced. About 20 percent of patients progress to viral hemorrhagic fever.
“Lassa virus has a high level of genetic diversity across much of West Africa,” said Dr. Robert Cross, associate professor in the Department of Microbiology & Immunology and one of the authors of the study. “This creates a real challenge for therapeutic developers as it raises the question of whether a single drug could be used to treat all Lassa virus infections.”
The UTMB research shows the potential of Zalgen Labs’ Arevirumab-3 therapeutic, a monoclonal antibody cocktail, as a treatment against all major disease strains in advanced stages.
The study concluded that the Arevirumab-3 therapeutic successfully treated cynomolgus monkeys when administered beginning at advanced stages of disease caused by two different major strains of Lassa virus that were involved in the research.
The results indicated Arevirumab-3 could potentially be used to treat humans infected with the Lassa virus.
Arevirumab-3 is on a path toward Investigational New Drug status with the U.S. Food and Drug Administration and toward projected Phase 1 clinical studies to assess its safety and efficacy in healthy human subjects.
“This study represents yet another proof that broad protective treatments, here against the highly complex and variable hemorrhagic fever Lassa virus, can be developed with cutting-edge research within secure high-containment laboratory environments,” said Dr. Gary Kobinger, director of the Galveston National Laboratory.
The finding is the result of an ongoing research collaboration between UTMB, Zalgen, and Tulane University. UTMB, along with Tulane, is conducting additional studies to further explore the use of Arevirumab-3 against divergent and emerging strains.