Bystander’ Cs meet their match in gene-editing technique
Biomolecular engineers at Rice University have found a C-worthy technique that dramatically enhances the accuracy of gene editing. The Rice lab of biomolecular engineer, Xue Sherry Gao, has introduced a set of tools that increase the accuracy of CRISPR-based edits in disease sequence models up to 6,000-fold compared with a current base editor, BE4max, that is considered state-of-the-art. Cytosine base editors are able to convert cytosines (C) to thymines (T) in the human genome, which...




